Innovative and exclusive VESIsorb® colloidal delivery system, for enhanced absorption and efficiency of orally administered CoQ10: Pharmacokinetic studies in humans have measured the relative bioavailability of Coenzyme Q10 with the VESIsorb® delivery system compared to standard oil-based CoQ10 products. VESIsorb® improved CoQ10 absorption by 622% compared to an oil-based formulation (Figure 1).² Bioavailability of CoQ10 is low due to its poor solubility in water. VESIsorb® improves absorption by imitating the naturally occurring mixed micellar transport system in the
human body. The CoQ10 is microscopically and evenly dispersed throughout the VESIsorb® delivery system allowing the transport of CoQ10 through the GI lumen to the absorptive epithelium (Figure 2).

Energy production: CoQ10 supports healthy mitochondrial function by assisting with energy production and protecting mitochondrial membranes from free radical damage.³

Cardiovascular health: Mitochondria are abundant in cardiomyocytes providing adequate ATP production for healthy cardiovascular function. CoQ10 exerts potent free radical scavenging activity in lipid and mitochondrial membranes, several clinical trials have shown CoQ10 to reduce the oxidation of LDL cholesterol. CoQ10 may also help to support healthy blood pressure in healthy people, by improving endothelium-dependant vasodilation and ß-adrenoceptor-mediated arterial relaxation. Individual’s on statin medications may benefit from CoQ10 supplementation as they deplete the body of CoQ10 by interfering with the production of mevalonic acid, a precursor in the synthesis of CoQ10.

Certain groups benefit from supplementing with the active (reduced) form of CoQ10, ubiquinol, over ubiquinone due to impaired endogenous conversion.⁸ Ubiquinone is converted to ubiquinol by NADH dehydrogenase, which passes electrons from NADH to ubidecarenone to form ubiquinol.⁹ This process can be hindered by high levels of oxidative stress and some medications. ^10,11,12