Th2 Modulator — designed to calm an over-active allergic response at its source, not just block the symptom

Most allergy products act at the very end of the chain, blocking histamine after it has already been released. Th2 Modulator is built on a different idea: to help rebalance the immune skew that drives an over-active allergic response in the first place. It combines four well-chosen actives — quercetin, perilla, astragalus and NAC — each working at a different level of that response, on Pure Encapsulations' hypoallergenic base.

Per 2 capsules: N-Acetyl-L-Cysteine (NAC) 300 mg · Quercetin 250 mg · Perilla (Perilla frutescens) seed extract 150 mg (3% polyphenols) · Astragalus (Astragalus membranaceus) root extract 160 mg.

The Th1/Th2 idea in one paragraph

The adaptive immune system can lean toward two broad modes: a Th1 (cell-mediated) response and a Th2 (antibody/allergic) response. In people with allergic and atopic tendencies, the Th2 arm is over-dominant — the mode associated with IgE antibodies, histamine release and the familiar hayfever and sensitivity picture. This formula is designed to modulate an over-active Th2 response and support a healthier Th1/Th2 balance. That upstream focus is what makes it unusual.

How each ingredient contributes

• Quercetin is a flavonoid that stabilises mast cells — the immune cells that store and release histamine. By steadying the mast-cell membrane, it helps reduce histamine release at the source, one step earlier than antihistamines that simply block the receptor afterwards.
• Perilla is traditionally used for respiratory and allergic support; its rosmarinic acid and luteolin help modulate the Th2-type inflammatory signals behind an over-reactive response.
• Astragalus is an adaptogenic immune tonic traditionally used to support balanced, resilient immune function — lending support to the Th1 side and helping shift the balance away from Th2 dominance.
• NAC is a precursor to glutathione, the body's master antioxidant, and is also a mucolytic — it breaks the disulfide bonds that make mucus thick, helping thin and clear it from the airways while topping up antioxidant reserves.

Who it may suit

Adults seeking to support a balanced immune response and healthy histamine regulation, particularly those with a seasonal or environmentally reactive, Th2-dominant tendency, and those wanting respiratory and antioxidant support.

How to take it

2 capsules, 1–2 times daily, between meals, or as directed by your healthcare professional.

Precautions

Astragalus supports immune activity — use with caution, and only under guidance, if you have an autoimmune condition or take immunosuppressant medication. If you are pregnant or breastfeeding, take prescription medication, or have an ongoing health condition, consult your healthcare professional before use. Always read the label and use only as directed.

This information is educational and describes how the ingredients work in the body. It is not medical advice and is not intended to diagnose, treat, cure or prevent any disease. If symptoms persist, consult your healthcare professional.